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Li L, Chen J, Zhou Y, Zhang J, Chen L

This suggests that reduced levels of GLP-1R in NOD mice and the type 1 diabetes patients we studied might play a role in the initial events that lead to inappropriate presentation and priming of anti-islet immune responses in the first place, and contribute to the beta cell fragility observed in previous studies (6)

Meanwhile, astragaloside IV can inhibit the Wnt/-catenin signaling pathway, degrade the ECM in renal tissue, and improve renal fibrosis (Chen et al., 2024c)